WebApr 1, 1993 · CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. N. Ohtani‐Fujita, T. Fujita, +3 authors T. Sakai Published 1 April 1993 Biology Oncogene Cytosine methylation of CpG sites in the promoter region of eucaryotic genes is involved in the inactivation of expression of certain genes. Webalternate reviewer. Funding was provided to the CPG devel-opment team for travel and expenses for CPG development training by the Orthopaedic Section, APTA, Inc. The CPG development team maintained editorial independence. Articles contributing to recommendations were reviewed based on specified inclusion and exclusion criteria with …

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